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Tinospora cordifolia (Giloy/Guduchi) Enhances Immunity in Children

The immune system in children is constantly developing and they are at an increased risk of infections. It is vital to help enhance immunity by vaccination but more people are turning towards traditional medicines today. The vast flora of the world offers newer options to this effect and is worth exploring. Tinospora cordifolia (Guduchi) is one such plant which has been traditionally used for various health conditions and is also proven to be an immunomodulator.

The mentioned clinical trial was published in The Journal of Phytopharmacology 2015, with an;

Objective: To evaluate the role of Tinospora cordifolia in status of immunity in children.

Materials and Methods: An open-labelled, placebo-controlled, randomized controlled trial was conducted in 400 children aged 1-15 years, with 200 each in control (given placebo-wheat flour) and test (given Giloy/Guduchi powder) groups.

Study drug (Giloy) and placebo (Wheat flour) were administered orally at a dose of 100 mg/kg body weight twice daily with honey for 2 months.

Response was assessed by total leucocyte count (TLC), lymphocyte percentage and absolute lymphocyte count (ALC). Results were analysed statistically using repeated measures Analysis of Variance (ANOVA) for intra-group comparisons and unpaired t-test for intergroup comparisons using Statistical Packages for Social Sciences (SPSS) software version 20.0.

Results: Among the 400 children included in the study, majority was males (54.5% in test group and 55.5% in control group) and aged 1-5 years (37.5% in test group and 41.5% in control group).

The effect of Tinospora cordifolia on laboratory parameters studied are shown that there was a significant increase in TLC, ALC and lymphocyte percentage on 30th day as well as 60th day as compared to 0th day in the test group and it was found that the rate of infections was significantly lower in test group.

No significant adverse effects were reported in both groups during the study period.

Conclusion: The study confirms the earlier claims of immunostimulatory properties of Tinospora cordifolia and offers a newer horizon to explore for boosting immunity in health or in immunodeficiency states. It can be concluded that Tinospora cordifolia can be used as an adjuvant to vaccination in order to boost the immune system in children.

Source: The Journal of Phytopharmacology

Research Article - ISSN 2230-480X | JPHYTO 2015; 4(4): 227-230 | July- August

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